For example, chronic unpredictable stress (CUS) in rodents causes depression-like behaviors that are accompanied by a decrease in MeCP2 and BDNF levels in the hippocampus, as well as an increase in miR-132, which is negatively correlated with MeCP2 and BDNF levels in blood samples from patients with depression [115]. This evidence concerns the gene MECP2 and major depressive disorder.