A significant shortening of the OS was associated with: the diagnosis of light chain disease or non-secreting MM (HR = 3.01), a higher disease stage according to the Durie–Salmon classification (III; HR = 3.06), worse kidney function (B; HR = 2.03), poor performance status (PS: 2–4; HR = 2.64), low albumin (HR = 2.29), high LDH (HR = 3.01), high calcium (HR = 1.88), high β2-microglobulin (B2M) level (HR = 3.12), and IGH/MAF fusion (HR = 21.92). The gene discussed is HLA-G; the disease is Miyoshi myopathy.