In keeping with the theme that high-level MYC amplification tends to be confined to certain tumor types (Figure 2) [104], deletion of presumptive TSGs tend to cluster as well, particularly in those instances associated with two copy deletion as seen with MLX and MNT in ovarian cancer, MXD2 in prostate cancer and MXD3 in squamous cell lung cancer (Figure 2) [104]. Here, MYC is linked to squamous cell lung carcinoma.