In addition to the up-regulation of several EMT-associated genes, and an array of E2F-regulated genes involved in cell cycle regulation and DNA replication, four of the five genes that were up-regulated in response to MGA inactivation in lung cancer (STAG3, PODXL2, NHLRC1, and ZCWPW1) were also up-regulated in MGA-knockout colonic organoids. This evidence concerns the gene MGA and lung cancer.