However, while potentially contributing to the evolution of adenomas, it seems unlikely that NAFLD per se was directly causative given that adenomas have not been observed in the livers of Myc−/−, Chrebp−/−or Myc−/−x Chrebp−/− mice [76] which also developed equally pronounced NAFLD [76]. The gene discussed is MYC; the disease is metabolic dysfunction-associated steatotic liver disease.