Our finding of the Dasatinib effect in decreasing renal fibrosis as observed through Sirius red staining and through a reduction in fibrogenic mediators, PDGFA, TGFβ and also decreased ASMA, is in accordance with the results of Hassan et al. [19], who reported slow progression of renal interstitial fibrosis induced by unilateral ureteral obstruction (UUO) in rats, possibly via suppressing renal oxidative stress, impairing Src/STAT-3/NF-kappaB signaling, reducing renal inflammation and, thus, reducing fibrogenic mediators: PDGFA, TGFβ and ASMA. This evidence concerns the gene ACTA1 and renal fibrosis.