Moreover, Elsayed et al. [13] found that Dasatinib could induce macrophage polarization towards decreasing inflammatory M1 macrophage and increasing M2 macrophage in a model of non-alcoholic steatohepatitis, as observed through downregulation of CD68 and iNOS with upregulation of CD163 and Arginase 1, respectively, thus deceasing hepatic inflammation and fibrosis. This evidence concerns the gene ARG1 and metabolic dysfunction-associated steatohepatitis.