Tumour-suppression activity of retinoic acid receptor-beta 2 (RAR-β2) is epigenetically downregulated by HBx via DNMT-driven hypermethylation, instigating upregulation of G1-checkpoint regulators p16, p21 and p27 and eventually E2F1 activation and ensued tumourigenesis [45,108]. Here, DNMT1 is linked to neoplasm.