ALOX5 and neoplasm: While a majority of these studies focus on HBx wild type, one landmark study has concluded that HBx mutant, HBxΔ127 promotes hepatoma cell migration by activating ossteopontin (OPN), a secreted phosphoprotein well implicated in mammalian epithelial cell transformation, through 5-LOX (another key enzyme tied to metabolism of arachidonic acid and often upregulated in several tumor types) [74].