That this pathway is unidirectional is supported by evidence that gene silencing of FOXA1 had no effect on the mRNA or protein expression of JAM-A in MCF7-HER2 cells (Figure 6A,B, respectively) or SK-BR-3 breast cancer cells (shown in the supplementary data of our recently published study [18]). This evidence concerns the gene ERBB2 and breast carcinoma.