H3K27 acetylation in entorhinal cortex samples from Alzheimer’s disease was found to be redistributed, particularly within loci related to disease-related genes, such as PSEN1 and PSEN2 [28], whereas in the lateral temporal lobe from AD patients, H3K27 and H3K9 acetylation was found to be globally increased, concurrently with a decreased expression of histone acetyl transferases [11] and H4K16 acetylation decrease [29]. The gene discussed is PSEN2; the disease is early-onset autosomal dominant Alzheimer disease.