Nuclear localisation of NS5 is central to DENV infection, being mediated by the nuclear transport factor Importin (IMP) α together with the IMPβ1 subunit [14]; preventing NS5:IMPα interaction by mutation of NS5 in the DENV genome or using small molecule inhibitors such as ivermectin [15,16,17,19] or N-(4-hydroxyphenyl) retinamide (4-HPR) [18], limits DENV infectious virus production, including in an ex vivo model of human infection [19], and in a mouse model of lethal DENV infection in the case of 4-HPR [18]. This evidence concerns the gene RAF1 and infection.