To further examine the impact of HOXA5 dysregulation in metabolic health, we analyzed promoter methylation in a group of obese individuals (Table S3; a detailed description of this cohort is provided in [9,11]), since, very much like those who are FDR, obese subjects also feature inappropriately enlarged adipocytes in their SAT and a high risk of developing T2D [26,27]. Here, HOXA5 is linked to type 2 diabetes mellitus.