DPYSL2 and colitis: As s-CRMP2 and pCRMP2 are required for cell division via mediating microtubule structure and appears to be a distinctive feature of highly proliferative cells [27], our findings suggest that, compared to colitis-CRC mice, increased inactive pCRMP2 in CRC-DM reflects advanced malignant potential probably due to pCRMP2-mediated cytoskeleton instability.