Similar to the observations in SW cells, pCRMP2 contributed to cell motility traits (Figure 4D): a transient but significantly reduced wound-healing ability of CRMP2-KD HCT15-Snail under euglycemic environment at 48 h was identified, while the decreased motility was compensated by hyperglycemia (200 and 450 mg/dL). This evidence concerns the gene SNAI1 and Hyperglycemia.