In brief, HFD-feeding DIO, DIO mice with diabetic onset (DM) induced by STZ injection, mice with colitis-CRC induced by receiving AOM and DSS administration (colitis-CRC), and diabetic DIO mice with CRC induced by combining all the above treatments (CRC-DM) were established as illustrated in Figure 5A. At the end of the experimental procedure, blood biochemical parameters were examined and colon tissue samples were collected to probe CRMP2 expression profiles. This evidence concerns the gene DPYSL2 and diabetes mellitus.