Notably, considering the findings of histological characteristics, higher CRMP2/Ki-67 and pCRMP2 in the lesions of CRC-DM compared to the non-diabetic colitis-CRC mice further support the fact that diabetic hyperglycemia upregulates s-CRMP2/pCRMP2 and thus takes part in accelerating CRC progression. Here, MKI67 is linked to diabetes mellitus.