DPYSL2 and colitis: In brief, HFD-feeding DIO, DIO mice with diabetic onset (DM) induced by STZ injection, mice with colitis-CRC induced by receiving AOM and DSS administration (colitis-CRC), and diabetic DIO mice with CRC induced by combining all the above treatments (CRC-DM) were established as illustrated in Figure 5A. At the end of the experimental procedure, blood biochemical parameters were examined and colon tissue samples were collected to probe CRMP2 expression profiles.