DPYSL2 and colorectal carcinoma: Furthermore, the current observation that s-CRMP2 is the predominant form detected in CRC cell lines (Figure 3A and Figure 4A), animal (Figure 6B) and human CRC tissues (Figure 2A) supports our previous finding that s-CRMP2 performs as a dominant regulator over f-CRMP2 to direct cell proliferation and cytoskeleton dynamics, and thus has a pathological role in tumorigenesis [18].