DPYSL2 and diabetes mellitus: Phosphorylated tCRMP2 (pCRMP2) and GSK-3β (pGSK-3β) were decreased in CRC-DM patients, however, phosphorylated f-CRMP2 (f-pCRMP2) and s-CRMP2 (s-pCRMP2) was the major pCRMP2 identified, respectively, in CRC and CRC-DM subjects (Figure 2).