Secondly, as colitis-CRC and CRC-DM mice served as the corresponding model for human CRC and CRC-DM subjects, the finding that hyperglycemia significantly downregulated CRMP2 (Figure 6C) not only further echoes lower CRMP2 detected in CRC-DM patients but also the association between glucose-mediated CRMP2 with CRC tumorigenesis [15,18]. Here, DPYSL2 is linked to diabetes mellitus.