The activation of p53, especially the phosphorylation of Ser15, has been reported to be indispensable in the TGF-β pathway in renal fibrosis development after ureteral obstruction, promoting the upregulation of fibrotic markers, including connective tissue growth factor (CTGF) and fibronectin [43]. This evidence concerns the gene TGFB1 and Ureteral obstruction.