The activation of p53, especially the phosphorylation of Ser15, has been reported to be indispensable in the TGF-β pathway in renal fibrosis development after ureteral obstruction, promoting the upregulation of fibrotic markers, including connective tissue growth factor (CTGF) and fibronectin [43]. The gene discussed is TGFB1; the disease is renal fibrosis.