To achieve robust tumor control via adoptively transferred T cells, our lab generated a hybrid Th1/17 (and Tc1/17) subset using novel ex vivo programming conditions that led to an increased proportion of T cells co-secreting high levels of IFNγ (Th1 signature cytokine) and IL-17 (Th17 signature cytokine) [93]. This evidence concerns the gene IFNG and neoplasm.