Furthermore, Sp1, a zinc finger transcription factor is also O-GlcNAcylated in response to high glucose concentrations and elevated Sp1 activity upon O-GlcNAcylation could play a role in hyperglycaemia-induced pro-fibrotic and pro-inflammatory factors involved in diabetic retinopathy [55,56]. This evidence concerns the gene SP1 and Hyperglycemia.