Increased cellular O-GlcNAc level which is typical in diabetes and insulin resistance is usually accompanied by NF-κB activation, and treatments that upregulate O-GlcNAcylation appear to have anti-inflammatory and pro-survival effects during acute injuries like myocardial infarction, burns, trauma and sepsis [69,70,107,108]. The gene discussed is NFKB1; the disease is Insulin resistance.