ADGRG2 and Ewing sarcoma: ADGRG2/GPR64 was also over-expressed in MTC (log2FC = 1.42, p = 0.0049) as in a number of carcinomas derived from breast cancer, parathyroid tumors, Ewing sarcomas, prostate, kidney or lung, and the inhibition of its expression promotes invasiveness and metastatic spread [45,46].