Although the presence of both cancer patients’ and healthy individuals’ monocytes increased IFN-γ secretion, the higher increase in IFN-γ secretion was seen by healthy individuals’ monocytes cultured with both autologous and allogenic NK cells in the presence of IL-2 + anti-CD16 mAbs treatment when compared to that of IL-2 treatment alone. The gene discussed is IFNG; the disease is cancer.