In the absence of monocytes, NK cells from cancer patients exhibited suppressed IFN-γ secretion when treated with IL-2 alone (Figure 3A,B, Figure 4A and Figure S3), or IL-2 + anti-CD16 mAbs (Figure 3A,C, Figure 4B and Figure S3), but increased IFN-γ secretion in cancer patients’ NK cells were seen when treated with IL-2 + sAJ2 (Figure 3A,D, Figure 4C and Figure S3). Here, IL2 is linked to cancer.