IGHG3 and systemic lupus erythematosus: In addition, it has been shown that the Cd19Cre/+ knock in allele leads to a decrease/increase of pre-B/IMB cells in the BM [19,21], an accelerated mortality in lupus-prone (NZB × NZW) F1 mice [21], a faster weight recovery post influenza infection [42], a slightly shorter life-span [43], as well as an augmented LPS-induced CSR to IgG3+ cells in vitro [45].