Moreover, whereas leptospirosis-infected wild-type mice demonstrated higher levels of plenty of cytokines, including IL-4, IL-10, and IL-13 compared with uninfected mice, Leptospira-induced murine chronic nephritis (Daf1-/- mice) showed higher expression of smooth muscle actin, IL-10, IL-13, but no difference of IL-12 and IL-17 levels [73]. This evidence concerns the gene IL10 and leptospirosis.