In addition, the dyskinesia scores of the monkeys used in the present study strongly correlated positively with their [3H]ABP688 specific binding in the putamen [23] and with the levels of Iba1 in the pre-commissural caudate and putamen, SN, GPe, and GPi as well as with the levels of CD68 in the pre-commissural putamen, suggesting that in this animal model, mGlu5 receptors modulation in the basal ganglia is intimately linked to cellular and molecular mechanisms associated with microglia-mediated inflammation and LID. Here, AIF1 is linked to drug-induced dyskinesia.