Given the presence of inflammation and infiltration of immune cells, including CD4 or CD8 T cells [110,134] especially in MRI STIR positive muscles in FSHD patients, Frisullo et al. (2011) [117] evaluated the presence of circulating activated immune cells and cytokines levels in FSHD patients with or without STIR positive muscles and from controls. The gene discussed is CD4; the disease is facioscapulohumeral muscular dystrophy.