In a recent cross-sectional study on 36 FSHD patients that examined the correlation between lower extremity MRI characteristics, muscle pathology and expression of DUX4 target genes, it was found that STIR positive muscle MRI measures exhibited a substantial predictive value for identifying muscles with DUX4 expression and active disease [116]. Here, DUX4 is linked to facioscapulohumeral muscular dystrophy.