Stimulates mitophagy:When localized in mitochondria, BAG6 promotes mitochondrial fission and PINK1/Parkin signaling [49].Involved in the localization of mitochondria to the perinuclear region [51]New receptor for mitophagy [49].Inhibits mitophagy in PD: Chronic MPP+ treatment increases the expression of BAG6 expression that interacts with PINK1 decreasing its stability [57]. The gene discussed is PRKN; the disease is Parkinson disease.