Figure 2e illustrates a subset of the most differentially expressed (avg(log2FC) < −0.4, avg(log2FC) > 0.4) AD-associated genes between the OM libraries. STC1, BCYRN1, CBX3, TFPI2, MMP1, PABPC1, MT-ATP8, and RPS10 were the top eight up-regulated DEGs, and SFRP2, MGP, IGFBP2, HTRA1, PRRX2, COL3A1, ELP5, and SFRP1 formed the top eight most down-regulated DEGs. The gene discussed is SFRP2; the disease is Alzheimer disease.