Depletion of suppressor of variegation 3–9 homolog 1 (SUV39h1), a histone H3 lysine 9 methyltransferase and a critical enzyme in SAHF formation, promoted tumor progression in a neuroblastoma Ras-induced oncogene transgenic mouse model, suggesting that SAHF are important in preventing neoplastic transformation [86]. The gene discussed is SUV39H1; the disease is neoplasm.