Through activation of an intracellular receptor, the glucocorticoid receptor (GR), GCs regulate a wide variety of systems in our body, including the immune system, metabolism, bone formation, and central nervous system, leading to side effects, such as infectious diseases, diabetes, osteoporosis, and depression, which severely limit the clinical use of these widely prescribed anti-inflammatory drugs [3]. The gene discussed is NR3C1; the disease is osteoporosis.