When VEGF-C-inhibited A549 cells were injected into the tail vein of nude mice, suppression of tumor growth, angiogenesis and lymphangiogenesis was demonstrated with a concomitant reduction of the CCR7-dependent Akt, ERK1/2 and p38 pathways, as previously described for other cancers [210]. The gene discussed is AKT1; the disease is neoplasm.