Murine oral squamous cell carcinoma cell line, B7E3, implanted in syngeneic Balb/c mice had a significantly higher rate of tumor growth and cervical lymph node metastasis compared to plt littermates, which, at least in part, could be overcome by overexpressing CCR7 in plt mice to counter the plt CCR7-activation defect [157]. The gene discussed is CCR7; the disease is oral cavity squamous cell carcinoma.