CIP4 was highly expressed in B-CLL cells and, when stimulated by CCL19/CCR7, CIP4 binds to GTP-associated Cdc42 and interacts with the leading edge of the cell lamellipodia, stimulating the forward migration in JVM3 B-CLL cells in vitro [265]. The gene discussed is CCR7; the disease is B-cell chronic lymphocytic leukemia.