Analysis of chemokine receptor expression in osteosarcoma cells found that 43% of the patient tumor samples expressed CCR7, although these levels were highly variable, such that CCR7 positivity per se did not correlate with overall patient survival; however, for high CCR7 expressers, there were statistically reduced overall survival and metastasis-free survival compared to low CCR7 expressors [242]. This evidence concerns the gene CCR7 and neoplasm.