By activating either the T-cell receptor for T-CLL or the B-cell receptor for B-CLL, CCR7 induced expression of the protein tyrosine kinase, ZAP70, increasing leukemia cell actin polymerization and migration, suggesting an alternative CCR7-linked actin-dependent migratory pathway in leukemia [256,271,272,273]. The gene discussed is ZAP70; the disease is B-cell chronic lymphocytic leukemia.