Related to actin cytoskeleton, using PCI-37B cells inhibition of Ras homolog family member A (RhoA), a small GTPase, attenuated the cancer cell migration and invasive properties induced by CCL19; conversely, CCL19 incubation activated RhoA, the non-receptor proline-rich tyrosine kinase, Pyk2 and increased cofilin activity and actin polymerization, effects that were prevented by anti-CCR7 monoclonal antibodies [188]. The gene discussed is CCR7; the disease is cancer.