In clinical lung adenocarcinoma tissue samples, both CCR7 and CXCR3 were expressed, with CXCR3 having a higher frequency, 90% vs. 65%; however, only CCR7 was associated with lymph node metastasis and not CXCR3 in these human tissues [215]. Here, CCR7 is linked to metastatic malignant neoplasm in the lymph nodes.