CCR7 expression varied depending upon the type of HL, with the classical subtype having mainly CCR7-positive cells located in the interfollicular zone of the lymph nodes, whereas the nodular lymphocyte-predominant subtype that associated with follicular structures had no CCR7 expression, although CXCR4 was highly expressed in this location [283]. The gene discussed is CCR7; the disease is Hodgkins lymphoma.