In vitro studies comparing Hut78 cells (cutaneous T-cell lymphoma) and Jurkat cells (adult T-cell lymphoma) revealed that CCR7 and MMP-9 levels were significantly higher in Hut78 cells compared to Jurkat cells, corresponding with elevated migration to CCL21 and suggesting that CCR7 plays a key role T-cell leukemia/lymphoma invasion [66,284]. This evidence concerns the gene CCR7 and primary cutaneous T-cell non-Hodgkin lymphoma.