AGTR1 and Myocardial fibrosis: AGTR1-Agtr1-induced myocardial fibrosis is either directly mediated by the angiotensin II stimulation of AGTR1-Agtr1 [133] or indirectly by the AGTR1-Agtr1-mediated induction of transforming growth factor beta 1, TGFB1-Tgfb1 [134].