The ANA test is a sensitive test that detects ARD but has low specificity; therefore, a positive ANA (titer > 1:80) should be followed by additional serologic tests, such as anti-Ro (SSA), anti-La (SSB), RNP, ds-DNA, Smith, scleroderma-70 and centromere antibodies. The gene discussed is SSB; the disease is scleroderma.