CASP3 and ovarian carcinoma: A recent study demonstrated that berberine (BBR), a potent anticancer drug, combined with cisplatin (DDP) enhanced apoptosis by inhibiting PCNA and Ki67 expression and upregulating caspase-3, caspase-8, RIPK3, and MLKL expression and activation in the OVCAR-3 and POCCL ovarian cancer cell lines [68] (Figure 2).