AKT1 and cancer: In particular, OC stemness (CSC), the key regulatory factor of aggressive cancer, is directly modulated by PI3K/PTEN/AKT signaling, causing CSC enrichment, CSC phenotyping maintenance, and multidrug resistance (MDR) [30,31], which leads to abnormal cell proliferation and cancer metastasis through epithelial–mesenchymal transition [32].