Here, Arabnezhab and colleagues [30] demonstrated that, once activated by the endogenous agonist FICZ, AhR interferes in the AR-mediated transcription of some genes, including TMPRSS2. The dependency of TMPRSS2 expression on male sexual steroids could be a contributing factor in explaining the higher incidence of COVID-19 in males. The gene discussed is TMPRSS2; the disease is COVID-19.