CEBPD is a well-known transcription factor and holds dual traits as a tumor suppressor in hepatocellular carcinoma [18], prostate cancer cells [19] or oncogene in lung adenocarcinoma [20], breast cancer [21] and UC [15] based on the diverse microenvironments of tumors [14,22,23,24,25]. This evidence concerns the gene CEBPD and hepatocellular carcinoma.