VEGFA belongs to the VEGF family (vascular endothelial growth factor; VEGFA, VEGFB, VEGFC, VEGFD, placenta growth factor [PGF]) and represents the best characteristics for angiogenesis to promote tumor growth and systemic metastasis (Carmeliet and Jain, 2011; Peach et al., 2018). Here, PGF is linked to neoplasm.