Finally, recessive missense mutations in cytochrome c have been associated with thrombocytopenia, whereas mutations in the X-linked gene encoding the holocytochrome c-type synthase (HCCS) gene is lethal in males and associated with non-canonical mitochondrial dependent apoptosis in females, which explains the associated phenotype of microphthalmia with linear skin lesions (MLS) [102]. The gene discussed is HCCS; the disease is microphthalmia.