Likewise, authors also demonstrated that syndecan-1 plays an essential role in the packaging of antifibrotic miRNAs in EVs, including miR-144-3p, miR-142a-3p, miR-142b, miR-503-3p, and miR-34b-5p, which have shown diverse effects on signaling pathways associated with fibroproliferation and fibrogenesis, suggesting that those miRNAs play a pivotal role in the regulation of IPF progress. The gene discussed is SDC1; the disease is idiopathic pulmonary fibrosis.