On the other hand, Yao et al. have demonstrated that macrophage-derived EVs bearing an M2 phenotype transport miR-328 and that this miRNA charge participates in promoting IPF progression by negatively regulating family with sequence similarity 13, member A (FAM13A) and as a result, inducing lung fibroblasts proliferation and overexpression of collagens 1A, 3A, and alpha-smooth muscle actin (α-SMA) [56]. Here, ACTA1 is linked to idiopathic pulmonary fibrosis.