Alternatively, fibroblasts from IPF patients have been reported to secrete EVs fibronectin-enriched, which promote an invasive phenotype in recipient fibroblasts through the interaction of fibronectin with α5β1 integrin, triggering the activation of signaling pathways associated with cell invasion processes, such as Src family kinases and focal adhesion kinase [49]. Here, FN1 is linked to idiopathic pulmonary fibrosis.