ACE2 and osteosarcoma: ACE2 was detected in lysates from cell lines originally derived from lung (Calu-1) and lung cancer (A549, H1299), mammary gland (Eph4) and mammary breast cancer (MCF-7, MDA-MB-231), colon cancer (SKCO15, Caco2), kidney collecting duct (mCCD), cervical cancer (HeLa), in myeloblastic-derived haploid fibroblasts (Hap1), in human osteosarcoma (U-2 OS) and epidermal (HaCaT) cells, with highest levels in HeLa and HaCat cells (Figure 2A,B).