For example, ACE2 interacts with ADAM17 (A Disintegrin And Metalloproteinase 17), which regulates the proteolytic shedding of the ACE2 ectodomain [23,24,25,26,27,28,29] and is also required for the infection of epithelial cells by oncogenic papillomaviruses, through the formation of a surface platform comprising the tetraspanin CD151 and the epidermal growth factor receptor (EGFR) [30]. The gene discussed is ACE2; the disease is infection.