HMOX1 and acute kidney injury: To look for a potential anti-oxidative role of asymptomatic HU in AKI/AKD, we performed RT-qPCR for known pro-oxidant and anti-oxidant markers and found that the intrarenal mRNA expression level of the pro-oxidant heme oxygenase (Ho)-1 increased on day 14 as compared with day 0 and 3 in non-HU mice after IRI (Figure 5C).