PPARD and colorectal carcinoma: Consistent with these results, PPAR-β/δ has been shown to strongly potentiate aberrant activation of β-catenin in mouse genetic models of human CRC, with representative APC mutations and overexpression or deletion of PPAR-β/δ in intestinal epithelial cells (IEC), activating pro-invasive pathways to promote CRC tumorigenesis.