TP53 and central nervous system cancer: Among the genetic risk factors, a set of single nucleotide genetic polymorphisms (SNPs) have been identified, located on different genes (NF1, NF2, IDH1/IDH2, TERT, EGFR, CCDC26, CDKN2B, PHLDB1, TP53, RTEL1), which seem to contribute to gliomagenesis and to the development of all grades and histologies of gliomas [3,4].