Ephatutazone has been shown to cause a 49.6% reduction in the proliferation of xenotransplanted ESCC cells through a mechanism that involves the regulation of p21Cip1 protein levels in the nucleus by inactivating the Akt signal and dephosphorylating p21 to Thr145, without altering the transcriptional activity of p21Cip1 [53]. This evidence concerns the gene CDKN1A and esophageal squamous cell carcinoma.