Some investigations have also confirmed that fenofibrate is a neuroprotective agent; the results obtained in vitro on high-grade glioma (HGG) cell lines U87 and U343 (p53 wild-type), U251 and T98 (p53 mutant), confirmed the antiproliferative and pro-apoptotic effects of fenofibrate demonstrating inhibition of NF-κB expression, cyclin D1, and Akt (Figure 4). This evidence concerns the gene AKT1 and central nervous system cancer.