LEP and liposarcoma: The role of PPAR-β/δ in enhancing cell proliferation was supported by a further study performed on human liposarcoma cells (SW872, T778), in which an increase in cell proliferation was observed in response to PPAR-β/δ activation by the agonist GW0742, which appears to be caused by leptin repression, suggesting the potential therapeutic use of PPAR-β/δ antagonists for the treatment of unresectable liposarcomas [46].