Anti-PD-1 monoclonal antibodies (mAbs) such as nivolumab, pembrolizumab and cemiplimab, and anti-PD-L1 mAbs atezolizumab and durvalumab target PD-1/PD-L1 binding function, by essentially removing the brakes from the anti-tumor immune response [13]. Here, PDCD1 is linked to neoplasm.