Using this model, the authors indicated that increased IL-15 leads to the spontaneous CTCL developed in SCID mice and the study concluded that excessive autocrine production of IL-15 inhibits negative autoregulatory loop for HDAC1, resulting in the upregulation of HDAC1 and HDAC6 and transcriptional induction of the onco-miR-21 [75]. Here, HDAC1 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.