The karyotype analysis of the cell lines and patient MF/SS samples revealed that structural changes can predict CTCL disease variant since loss at 10q24 region was observed in biospecimens from SS patients as well as in blood-derived cell lines including SeAx, Sez4, SZ4, H9, Hut78 and HH, but not in skin-derived MF (MyLa and HH) and CD30+ LPD (PB2B and Mac2A) cell lines [36]. Here, TNFRSF8 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.