Numerous RG/RGG-containing proteins have been implicated in neurological disorders, such as FUS and TAF-15 in ALS, FXR1, and FMRP1 in fragile X syndrome (FSX), SMN in spinal muscular atrophy (SMA), SHANK1 in autism, as well as a plethora of human cancers [44]. This evidence concerns the gene SHANK1 and amyotrophic lateral sclerosis.