While accumulating evidence has shown the physiological importance of AMPK in regulating IEB function under homeostatic conditions [11,19], first, we questioned the role of IEC AMPK in the pathogenesis of colitis by using the DSS-induced experimental colitis model, in which acute intestinal inflammation with epithelial loss is induced by treatment with DSS [20]. The gene discussed is PRKAA2; the disease is colitis.