PRKAA1 and colitis: Histologic examination of Swiss-rolled colons in the colitis recovery period demonstrated a typical histological architecture in WT mice with predominant distal injury characterized by epithelial ulceration and inflammatory infiltrates, whereas IEC AMPK KO mice displayed a larger area of epithelial erosion with more pronounced mucosal ulceration, and more massive inflammatory cell infiltration (Figure 2G–I).