TP53 and cancer: Although lung cancer is not commonly associated with hereditary cancer susceptibility and is environmentally provoked, a subset of lung adenocarcinoma patients (2.5%-4.5%) may be linked to germline variants in well-known predisposing cancer genes such as ATM (50%), BRCA2, or TP53. 61Besides, germline EGFR mutations (e.g. T790M) were reported that may be difficult to discriminate from their targetable somatic counterpart in ctDNA mutation testing when no PBMC analysis is included in parallel.62