On comparison among GBM subtypes, cystatin B (CTSB) was elevated for PRO compared to MES and CLA subtype, and hemicentin-2 (HMCN2) and plexin-B1, which were increased and decreased for PRO versus CLA subtype, respectively (supplemental Fig. S4B). The gene discussed is PLXNB1; the disease is glioblastoma.