However, we found that integrin α5β1 acted as a receptor for AGGF1 in endothelial cells, activated FAK-Src-AKT signaling, and modulated the signaling and functions of AGGF1 in endothelial cells and therapeutic angiogenesis in a model for peripheral artery disease (PAD) (16). The gene discussed is AKT1; the disease is peripheral arterial disease.