SOD1 is an antioxidant that converts superoxide into molecular oxygen and hydrogen peroxide.58 There are numerous amyotrophic lateral sclerosis-linked SOD1 mutations.59,60 SOD1 protein aggregates are characteristic of amyotrophic lateral sclerosis patients with SOD1 mutations and are the second most common pathological subtype of amyotrophic lateral sclerosis. Here, SOD1 is linked to amyotrophic lateral sclerosis.