Of these identified proteins, 11 were altered in both diseases and six proteins were validated; cartilage oligomeric matrix protein, EGF containing fibulin extracellular matrix protein-1, FBLN1, gelsolin and protein S in frontotemporal dementia and creatinine kinase M-type, cartilage oligomeric matrix protein and gelsolin in amyotrophic lateral sclerosis.148 Inconsistency in the findings so far highlight the need for more thorough MS proteomics studies, particularly using plasma or serum. Here, COMP is linked to amyotrophic lateral sclerosis.