Abnormal regulation of the IL8-CXCR1/2 axis was implicated in a few inflammatory-mediated diseases, such as chronic obstructive pulmonary disorders, asthma, psoriasis, or rheumatoid arthritis, where IL8 plays a vital role in the recruitment of neutrophils and other immune cells to the site of infection [17]. The gene discussed is CXCL8; the disease is rheumatoid arthritis.