PGF and preeclampsia: Women with established PE have increased circulating levels of soluble fms-like tyrosine kinase 1 (sFlt-1), an antiangiogenic protein largely produced in the placenta, which is associated with inhibition of vascular endothelial growth factor and placental growth factor (PlGF) signalling in the vasculature [11–16]; hence, development of assays for biochemical markers such as angiogenic factors could be incorporated into more precise definitions of preeclampsia and help to improve prediction and diagnosis of PE [17].