Moreover, Tgm2 regulates various biological comportments of tumour cells, including differentiation, invasion, adhesion, apoptosis, migration, proliferation, survival, growth, interaction with microenvironment metastasis, angiogenesis and chemoresistance through mechanisms including pro-crosslinking, protein binding, signal transduction and transformation via microvesicles [39]. This evidence concerns the gene TGM2 and neoplasm.