CD4 and Acanthamoeba infectious disease: Nachega et al. described a case of aggressive rhinosinusitis, secondary to Acanthamoeba infection, in a patient with advanced HIV (CD4 cell count of 100 cells/μL) that was successfully treated with high-dose amphotericin B and 5-fluorocytosine, in addition to surgical debridement of the affected sinuses [19].