Another case report by Paltiel et al. described a good clinical response to the treatment of disseminated cutaneous acanthamoebiasis in a patient with advanced HIV (CD4 cell count of 3 cells/μL) using a combination of intravenous pentamidine, oral 5-fluorocytosine and sulfadiazine [20]. This evidence concerns the gene CD4 and Acanthamoeba infectious disease.