These two genes appeared in many GO functions such as positive regulation of cell death, TNF signaling pathway, response to steroid hormone, response to oxygen levels, regulation of mitogen-activated protein kinase (MAPK) cascade, fluid shear stress and atherosclerosis, p38MAPK cascade, response to peptide, cellular response to growth factor stimulus, response to chemokine, and response to wounding (Figure 4C). This evidence concerns the gene TNF and atherosclerosis.