In support of the latter concept, LINC00152 on chromosome 2 is highly expressed in an array of tumor types and has been shown to promote metabolism, proliferation, cell survival, growth, and angiogenesis through disruption of various pathways such as PI3K/AKT, mTOR, IL-1, and NOTCH-1 signaling [43]. The gene discussed is NOTCH1; the disease is neoplasm.