FZD8 and fibrosis: A previous study showed that TGF-β induced fibroblast activation In vitro (MRC5 cells and primary human lung fibroblasts) and bleomycin-induced fibrosis in mice (FZD8-deficient mice) is regulated via FZD8 with WNT5B as the ligand [47], suggesting that the lncRNA AL121749.2 might be a novel lncRNA implicated in this mechanism.