ITGB1 and neoplasm: We found that ITGB1 transcript was significantly underexpressed in metastatic tissue compared to tumor and normal tissue in MSKCC samples (p-value ≤ 0.05 and ≤0.01, respectively) and in tumor tissue compared to normal tissue in PRAD-TCGA samples (p-value ≤ 0.0001) (Figure 3A,B), suggesting a tumor suppressor role of ITGB1 in PrCa.